Creatine supplementation: a novel role in antioxidant system in exercise and in chronic diseases

Authors

  • Giuseppe Potrick Stefani Universidade Federal de Ciências da Saúde de Porto Alegre
  • Ramiro Barcos Nunes Universidade Federal de Ciências da Saúde de Porto Alegre
  • Claudia Ramos Rhoden Universidade Federal de Ciências da Saúde de Porto Alegre

DOI:

https://doi.org/10.21527/2176-7114.2014.27.32-43

Keywords:

Saúde, Nutrição, Educação Física

Abstract

The effects of creatine supplementation related to ergogenic action which increases maximum strength and body mass has been extensively revised. In the least years it has been hypothesized a novel function of creatine as antioxidant agent. There are few data of this amine on oxidative stress and its role in antioxidant system. A small amount of studies in vitro and in vivo showed  promising results related to indirect antioxidant effect, which evaluated  the isolated supplementation protocols or added to standard diet. Creatine supplementation seems to exert positive effect on health, mainly in exercise conditions due to the ergogenic action. Furthermore, some evidences suggest that the supplementation might have positive effects on energy metabolism and functional capacity in chronic degenerative diseases. Expressive results were observed in Parkinson's disease and Huntington's disease, in which the creatine might acts as neuroprotective agent, neutralizing the reactive oxygen and nitrogen species action. The modulation of mitochondrial creatine kinase seems to play an important role in reactive oxygen species production, such as radical anion superoxide. This review aims to show the scientific evidences about antioxidant effect of creatine supplementation, when utilized alone or associated with physical exercise, in health individuals and in patients with chronic degenerative diseases.

Author Biographies

Giuseppe Potrick Stefani, Universidade Federal de Ciências da Saúde de Porto Alegre

Nutricionista formado pela UFCSPA (Universidade Federal de Ciências da Saúde de Porto Alegre), mestrando do Programa de Pós-Graduação em Ciências da Saúde pela UFCSPA (Universidade Federal de Ciências da Saúde de Porto Alegre), área de especialidade em Fisiologia e Patogênese, pós-graduando em Nutrição Clínica e Esportiva pelo iPGS (Instituto de Pesquisa e Gestão em Saúde).

Ramiro Barcos Nunes, Universidade Federal de Ciências da Saúde de Porto Alegre

Educador Físico formado pela UFRGS (Universidade Federal do Rio Grande do Sul), mestre e doutor em Ciências da Saúde pela UFCSPA (Universidade Federal de Ciências da Saúde de Porto Alegre), pós-doutorando pela UFCSPA (Universidade Federal de Ciências da Saúde de Porto Alegre).

Claudia Ramos Rhoden, Universidade Federal de Ciências da Saúde de Porto Alegre

Farmacêutica formada pela UFRGS (Universidade Federal do Rio Grande do Sul), mestre em em Farmacologia pela UFCSPA (Universidade Federal de Ciências da Saúde de Porto Alegre), doutora em Ciências Biológicas pela UFRGS (Universidade Federal do Rio Grande do Sul), pós-doutorado em Fisiologia com ênfase em Ciência Ambiental pela Harvard University. Atualmente é professora adjunta e coordenadora do Programa de Pós-Graduação em Ciências da Saúde na UFCSPA (Universidade Federal de Ciências da Saúde de Porto Alegre).

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Published

2015-03-05

How to Cite

Stefani, G. P., Nunes, R. B., & Rhoden, C. R. (2015). Creatine supplementation: a novel role in antioxidant system in exercise and in chronic diseases. Revista Contexto & Saúde, 14(27), 32–43. https://doi.org/10.21527/2176-7114.2014.27.32-43

Issue

Vol. 14 No. 27 (2014): Jul-Dez

Section

Exercício Físico & Saúde

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