Association of polymorphisms in gastric cancer in latin american individuals: A brief systematic review

Authors

DOI:

https://doi.org/10.21527/2176-7114.2026.51.16661

Keywords:

Stomach Neoplasms,, Gene Polymorphism, South American Peoples, Genetics

Abstract

Objective: To systematically compile all information that clarifies which genetic polymorphisms are associated with gastric cancer in South American individuals. Methods: A systematic review was conducted following the PRISMA model and PICO strategy, based on the guiding question: “Which genetic polymorphisms are related to gastric cancer in the Latin American population?” Articles were searched in the PubMed, LILACS, BVS, and Google Scholar databases, following defined inclusion and exclusion criteria. Fifty-two articles were found, and after analysis, 12 were definitively included in the review. Results: Several polymorphisms were identified in various genes involved in gene regulation, protein coding, inflammatory processes, oncological malnutrition, and drug-gene interaction, acting as potential molecular markers for the development of gastric cancer. Conclusion: The discovery of possible biomarkers that guide the relationship between gastric cancer and the polymorphisms of the genes studied in this review is promising. However, further studies are needed to better investigate this relationship and clarify the development of this pathology based on variations in various genes, allowing for future diagnostic approaches based on Single Nucleotide Polymorphism and genetic intervention in gastric cancer.

References

1. Lazarevic K, Nagorni A, Rancic N, Milutinovic S, Stosic L, Ilijev I. Dietary factors and gastric cancer risk: hospital-based case control study. J Buon. 2010;15(1):89-93.

2. Carvalho JB, Salgado NA, Silva ACM, Ramos EMLS, Demachki S, Araújo MS Moreira Da Silva A, Leal M, Ramos S, Demachki S, et al. Nutritional and socioenvironmental risk factores involved in gastriccarcinogenesis. Rev para. med. 2011;25(2/3)

3. Pereira L, Zamudio R, Soares-Souza GB, Herrera P, Cabrera L, Hooper CC, Cok J, Combe JM, Vargas G, Prado WA, Schneider S, Kehdy F, Rodrigues MR, Chanock SJ, Berg DE, Gilman RH, Tarazona-Santos E. Socioeconomic and nutritional factors account for the association of gastric cancer with Amerindian ancestry in a Latin American admixed population. 2012;7(8):e41200–0.

4. Zilberstein B, Malheiros C, Lourenço LG, Kassab P, Jacob CE, Carlos AC, Bresciani CJC, Castro O, Gama-Rodrigues J, Grupo Consenso. Brazilian consensus in gastric cancer: guidelines for gastric cancer in Brazil. Arq Bras Cir Dig. 2013;26(1):2–6.

5. Amorim CA, Moreira JP, Rial L, Carneiro AJ, Fogaça HM, Elia C, Luiz RR, Souza HSP. Ecological study of gastric cancer in Brazil: Geographic and time trend analysis. World J Gastroenterol. 2014;20(17):5036-5044.

6. Giusti ACBS, Salvador PTCO, Dos Santos J, Meira KC, Camacho AR, Guimarães RM, Souza DLB. Trends and predictions for gastric cancer mortality in Brazil. World J Gastroenterol. 2016;22(28):6527-6538.

7. Resende ALS, Mattos IE, Koifman S. Diet and gastric cancer: historical aspects associated with dietary patterns in the state of Pará, Brazil. RevNutr. 2006;19(4):511–519.

8. Shilan A, Kasmaei P, Farmanbar R, Shakiba M, Mahdaviroushan M, Zareban I, Mohammadkhah F, Soodmand M. Factors predicting nutritional behaviors related to gastric cancer: a model-guided study. Drug Invention Today. 2018;10(6):936.

9. Vahid F, Rahmani G, Naeini AJ, Falahnejad H, Davoodi SH. The Association Between Index of Nutritional Quality (INQ) and Gastric Cancer and Evaluation of Nutrient Intakes of Gastric Cancer Patients: A Case-Control Study. Int J Cancer. 2018;11(1):e9747.

10. Pabla BS, Shah SC, Corral JE, Morgan DR. Increased Incidence and Mortality of Gastric Cancer in Immigrant Populations from High to Low Regions of Incidence: A Systematic Review and Meta-Analysis. Clin Gastroenterol Hepatol. 2020;18(2):347-359.e5.

11. Santiago SB, Sousa GR de, Ramos AFPL, Fernandes GA, Curado MP, Barbosa MS. Exploratory Analysis of Dietary Patterns of Patients With Gastric Adenocarcinoma: A Case-Control Study in Central Brazil. Arq Gastroenterol. 2023;60:419–30.

12. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. 2022;46:e112

13. Santos CMC, Pimenta CAM, Nobre MRC. The PICO strategy for the research question construction and evidence search. Rev Lat Am Enfermagem. 2007;15(3):508–511.

14. Canto GL, Stefani CM, Massignan C. Risco de viés em revisões sistemáticas: guia prático. Centro Brasileiro de Pesquisas Baseadas em Evidências – COBE UFSC. 2021 [cited 23 May 2024]. Available from: https://guiariscodeviescobe.paginas.ufsc.br/

15. Réus JC, Honnef LR, Massignan C, Stefani CM, Canto GLuca. Análise da qualidade metodológica de estudos observacionais (coorte, caso-controle e transversal) com as ferramentas do Joanna Briggs Institute (JBI). Risco de viés em revisões sistemáticas: guia prático. Cap. 11. Centro Brasileiro de Pesquisas Baseadas em Evidências – COBE UFSC, 2021. [cited 23 May 2024]. Available from: https://guiariscodeviescobe.paginas.ufsc.br/capitulo-11-analise-da-qualidade-metodologica-de-estudos-observacionais-coorte-caso-controle-e-transversal-com-as-ferramentas-do-joanna-briggs-institute-jbi/.

16. Bitencourt, FV, Oliveira LB, Massignan C; Stefani CM, Canto GL. Análise da qualidade metodológica de estudos observacionais (coorte e caso-controle) com a ferramenta Newcastle-Ottawa Scale (NOS). Risco de viés em revisões sistemáticas: guia prático. Cap. 10. Centro Brasileiro de Pesquisas Baseadas em Evidências – COBE UFSC, 2021 [cited 23 May 2024]. Available from: https://guiariscodeviescobe.paginas.ufsc.br/capitulo-10-analise-da-qualidade-metodologica-de-estudos-observacionais-coorte-e-caso-controle-com-a-ferramenta-newcastle-ottawa-scale-nos/.

17. Dantas RN, Souza AM, Herrero SST, Kassab P, Malheiros CA, Lima EM. Association between PSCA, TNF-α, PARP1 and TP53 Gene Polymorphisms and Gastric Cancer Susceptibility in the Brazilian Population. Asian Pac J Cancer Prev. 2020;21(1):43-48

18. Fu L, Lei C, Chen Y, Xu X, Wu B, Dong L, Ye X, Zheng L, Gong D. Association of the rs3917647 polymorphism of the SELP gene with malnutrition in gastric cancer. Support Care Cancer. 2023;31(12):708.

19. Fernandes MR, Rodrigues JCC, Dobbin EAF, Pastana LF, Costa DF, Barra WF, Modesto AAC, Assumpção PB, Silva ALC, Santos SEB, Burbano RMR, Assumpção PP, Santos NPC. Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon. Cancer Chemother Pharmacol. 2021;88(5):837–844.

20. Andrade RB, Cohen-Paes AN, Leal DFVB, Pantoja KBCC, Gellen LPA, Carvalho DC, Souza TP, Fernandes MR, Assumpção PP, Burbano RMR, Santos SEB, Santos NPC. Impact of pri-let-7a-1 rs10739971 for Gastric Cancer Predisposition in an Amazon Region. Genes (Basel). 2023;14(2):453.

21. Fu L, Lei C, Chen Y, Zhu R, Zhuang M, Dong L, Ye X, Zheng L, Gong D. TNF-α-1031T/C gene polymorphism as a predictor of malnutrition in patients with gastric cancer. Front Nutr. 2023;10:1208375.

22. Felipe AV, Silva TD, Pimenta CA, Kassab P, Forones NM. lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population. Biol Res. 2012;45(4):369–374.

23. Oliveros-Wilches R, Pinilla-Morales RE, Sánchez-Pedraza R, Facundo-Navia H, Sánchez-Cortés EF, Buitrago-Gutiérrez DA. Morbilidad y mortalidad en pacientes llevados a gastrectomía por cáncer gástrico. Revista Colombiana de Cirurgía. 2023;38(3):459-467.

24. Vinagre RMDF, Campos BP, Sousa RMP. Case study of stomach adenocarcinoma conducted at a cancer referral hospital in northern Brazil. Arq Gastroenrol. 2012;49(2):125-129.

25. Oliveira JG, Silva AE. Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population. World J Gastroenterol. 2012;18(11):1235–1242.

26. Colombo J, Rossit ARB, Caetano A, Borim AA, Wornrath D, Silva AE. GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population. World J Gastroenterol. 2004;10(9):1240–1245.

27. Lima EM, Leal MF, Smith MAC, Burbano RR, Assumpção PP, Bello MJ, Rey JA, Lima FF, Casartelli C. DNA mismatch repair gene methylation in gastric cancer in individuals from northern Brazil. Biocell. 2008;32(3):237–243.

28. Guindalini RSC, Cormedi MCV, Maistro S, Pasini FS, Branas PCAA, Santos L, Pereira GFL, Bock GH, Saccaro DM, Katayama MLH, Faraj SF, Safatle-Ribeiro A, Junior UR, Diz MDPE, Gouvêa ACRC, Chammas R, Folgueira MAAK. Frequency of CDH1 germline variants and contribution of dietary habits in early age onset gastric cancer patients in Brazil. 2019;22(5):920–931.

Downloads

Published

2026-03-25

How to Cite

Gomes , M. J. dos S., dos Reis, C. R., Brigida, M. D. C. S., de Oliveira, M. E. C., Costa, P. A. G., de Oliveira, H. S. S., … de Oliveira, R. de C. S. de O. (2026). Association of polymorphisms in gastric cancer in latin american individuals: A brief systematic review. Revista Contexto & Saúde, 26(51), e16661. https://doi.org/10.21527/2176-7114.2026.51.16661

Issue

Vol. 26 No. 51 (2026): 2026

Section

REVIEW ARTICLE

License

Copyright (c) 2026 Maervily Jacqueline dos Santos Gomes, Claudia Rodrigues dos Reis, Marcio Deyvid Corrêa Santa Brigida, Maria Elisa Costa de Oliveira, Pedro Afonso Gomes Costa, Haiala Soter Silva de Oliveira, Erik William Farias Coelho, Victor Leno Silva Paes, Rita de Cássia Silva de Oliveira de Oliveira

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

By publishing in Revista Contexto & Saúde, authors agree to the following terms:

The works are licensed under the Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)  license, which allows:

Share — to copy and redistribute the material in any medium or format;

Adapt — to remix, transform, and build upon the material for any purpose, including commercial.

These permissions are irrevocable, provided that the following terms are respected:

Attribution — authors must be properly credited, with a link to the license and indication of any changes made.

No additional restrictions — no legal or technological measures may be applied that restrict the use permitted by the license.

Notes:

The license does not apply to elements in the public domain or covered by legal exceptions.

The license does not grant all rights necessary for specific uses (e.g., image rights, privacy, or moral rights).

The journal is not responsible for opinions expressed in the articles, which are the sole responsibility of the authors. The Editor, with the support of the Editorial Board, reserves the right to suggest or request modifications when necessary.

Only original scientific articles presenting research results of interest that have not been published or simultaneously submitted to another journal with the same objective will be accepted.

Mentions of trademarks or specific products are intended solely for identification purposes, without any promotional association by the authors or the journal.

License Agreement (for articles published from September 2025): Authors retain copyright over their article and grant Revista Contexto & Saúde the right of first publication.