Acute Phase Proteins: Old tools improving tuberculosis diagnosis
DOI:
https://doi.org/10.21527/2176-7114.2023.47.13923Keywords:
Tuberculosis; Antitubercular Agents; Acute-Phase ReactionAbstract
Rapid identification of new cases of tuberculosis and monitoring of patients during antituberculosis treatment are important tools for disease control. Thus, the objective of the present study was to evaluate acute phase markers of patients with tuberculosis during antituberculosis treatment and their association with clinical, laboratory and radiological parameters. Therefore, a study with a quantitative approach was carried out, in which, the levels of C-reactive protein (CRP), albumin (ALB) and the CRP/ALB ratio of patients with tuberculosis (n=37) treated in a city in the Western São Paulo region, were evaluated at different times of antituberculosis treatment: T1 (1 and 2 months; n =16), T2 (3 and 4 months; n=11) and T3 (5 and 6 months; n=10) and controls (n=21). The risk of complications from inflammatory stress was associated with different levels of CRP/ALB ratio. Clinical, laboratory and radiological data of patients obtained through analysis of medical records. It was demonstrated that the levels of CRP and CRP/ALB ratio were elevated in T1 compared to T2. The CRP/ALB ratio demonstrated an association with a higher risk of complications from inflammatory stress at T1, with a decreased risk at T2. There was a decrease in CRP and CRP/ALB ratio from T1 to T2 in patients with positive bacilloscopy (1+) and with the presence of fever and other symptoms. We conclude that CRP and CRP/ALB ratio can be used as markers for diagnosis and antituberculosis treatment and the association CRP/ALB ratio with the risk of complications from inflammatory stress in monitoring the effectiveness of the treatment.
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