Análise dos polimorfismos RS10750097 e RS3741298 dos genes da APOA5 em relação as dislipidemias

Autores/as

DOI:

https://doi.org/10.21527/2176-7114.2025.50.15567

Palabras clave:

Dislipidemia, APOA5, ZNF, polimorfismo, militares, genes

Resumen

A Dislipidemia é caracterizada por um distúrbio no metabolismo de lipídeos e surge devido a causas externas, ou distúrbios genéticos predisponentes. O presente estudo observacional transversal teve como objetivo a análise da correlação entre os polimorfismos genéticos RS10750097 e RS3741298 associados a lipoproteína ApoA5- ZNF259 e o desenvolvimento de dislipidemia. Foi utilizada uma amostra de 200 Policiais Militares do Estado de Goiás e realizada a genotipagem dos polimorfismos. Dos indivíduos participantes 93% eram do sexo masculino e 7% do sexo feminino. Os polimorfismos observados nos grupos com dislipidemia e sem dislipidemia mostraram diferença significativa entre os dois grupos para todas as variáveis analisadas (p<0,05). O presente estudo identificou que os polimorfismos RS10750097 e RS3741298 não aumentaram a razão de chance de o grupo com dislipidemia apresentar de fato dislipidemia (OR e 95% IC<1), o que corrobora com estudos anteriormente descritos em populações distintas. Assim sendo, os polimorfismos RS10750097 e RS3741298 não influenciaram, então, no desenvolvimento de dislipidemia dentro das variáveis envolvidas nesse estudo e nessa população, apesar de fazerem parte do espectro de SNPs da APOA5 região ZNF 259. Observa-se, assim, a influência da epigenética de cada população nos resultados e a necessidade de pesquisas do gênero em outros grupos alvo.

Citas

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Publicado

2025-07-30

Cómo citar

Saad, F. G. A., Campos, L. M. C., Gomes, C. M., Castro, F. S., & Costa, S. H. N. (2025). Análise dos polimorfismos RS10750097 e RS3741298 dos genes da APOA5 em relação as dislipidemias. Revista Contexto & Saúde, 25(50), e15567. https://doi.org/10.21527/2176-7114.2025.50.15567

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