TRADUÇÃO E VALIDAÇÃO DE ALGORITMO PARA IDENTIFICAÇÃO DE LESÃO HEPÁTICA INDUZIDA POR MEDICAMENTOS
DOI:
https://doi.org/10.21527/2176-7114.2020.40.226-235Keywords:
Chemical and Drug Induced Liver Injury, Chronic; Drug-Related Side Effects and Adverse Reactions; Liver Failure, Algorithms.Abstract
Introduction: Drug induced liver injury is a type of adverse drug reaction. Its occurrence is the cause of fulminant liver failure in 13% to 30% of cases. The. Russel Uclaf Causality Assessment Method (RUCAM) is a specific algorithm for the determination of drug-induced liver disease. The aim is to translate and validate the RUCAM algorithm into the Portuguese. Methods: The translation and the inverse translation of the algorithm was performer. The validation of content verified by the application of the algorithm translated to a real case, by doctors, pharmacists and nurses. Results: 41 valid answers were obtain. The average time for the application was 17 + 10 minutes. The mean score observed was 7.58 + 3.48 (probable causal relationship). The score differences found between the different professional categories were not statistically significant (p = 0.800). Discussion: The RUCAM algorithm has seven domains: time of onset of liver disease, duration of disease, risk factors, concomitant use of drugs, and exclusion of alternative causes, previous virus history, and response to drug exposure. Such information allows greater accuracy in the confirmation of suspected adverse reaction, favoring the identification of drugs with hepatotoxic potential. Conclusion: The Portuguese translated RUCAM algorithm proved to be a useful tool for investigating causality between liver injury and drugs, which can be apply by doctors, nurses and pharmacists.
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